Relationship between GFAP,UCH-L1 and CT findings and outcome in patients with severe traumatic brain injury
10.3969/j.issn.1671-8348.2013.34.005
- VernacularTitle:严重颅脑损伤后血清 GFAP 、UC H-L1与 CT 表现及预后的关系
- Author:
Jianping DENG
;
Xiaochuan SUN
;
Ke LIU
- Publication Type:Journal Article
- Keywords:
traumatic brain injury;
glial fibrillary acidic protein;
CT;
ubiqutin carboxy-terminal hydrolase L1;
outcome
- From:
Chongqing Medicine
2013;(34):4117-4119
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the levels of serum glial fibrillary acidic protein (GFAP) ,ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) ,CT findings and outcome in patients with severe traumatic brain injury .Methods En-zyme linked immunosorbent assay (ELISA) was conducted to detect the serum level of GFAP and UCH-L1 in 62 patients with se-vere traumatic brain injury at the time of 12 h and 36 h after the trauma .CT scans of the brain were obtained within 12 h of injury . Outcome was assessed by glasgow outcome scale (GOS) at 6th month .The relationship between GFAP ,UCH-1 ,CT findings and outcome were analyzed .56 healthy persons were selected as control group .Results The concentrations of serum GFAP and UCH-L1 of patients were significantly higher than those of the control group (P< 0 .05) ;GFAP levels were higher in patients with mass lesions than in those with diffuse injury while UCH-L1 levels were higher in patients with diffuse injury (P< 0 .05) ;the levels of GFAP and UCH-L1 of patients with unfavourable outcome(GOS 1 - 3 scores) were significantly higher than those of patients with favourable outcome(GOS 4 - 5 scores) ,and the concentrations of biomarkers were significantly negatively correlated with outcome . Conclusion Serum levels of GFAP and UCH-L1 are good predictors for severity and outcome in severe traumatic brain injury (TBI) .The levels of GFAP and UCH-L1 could reflect different injury pathways which were different in patients with mass lesions and diffuse injury remarkbly .GFAP and UCH-L1 could provide better characterization of subjects for specific types of cellular dam -age than that obtained with CT alone .
