Evaluation of dialysis in patients with end-stage renal disease by salivary urea, creatinine and uric acid
10.3969/j.issn.1672-7347.2013.12.009
- VernacularTitle:唾液尿素、肌酐、尿酸水平评估临床终末期肾病的透析效果
- Author:
Ping CHENG
;
Yuncheng XIA
;
Canhui PENG
;
Zhifang ZHOU
- Publication Type:Journal Article
- Keywords:
saliva;
urea;
creatinine;
uric acid;
end-stage renal disease;
hemodialysis
- From:
Journal of Central South University(Medical Sciences)
2013;38(12):1260-1263
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the changes of saliva urea, creatinine (Cr), and uric acid (UA) before and after hemodialysis in patients with end-stage renal disease (ESRD), and to evaluate the clearing effect of Urea, Cr, and UA.
Methods:Saliva and serum (2 mL) were collected from the dialysis patients. The concentrations of Urea, Cr, and UA in both samples were measured by biochemical analyzer. The concentrations of Urea, Cr, and UA in the saliva and the serum, and their correlation were analyzed. Before and after the hemodialysis, the reduction ratio (RR) of Urea, Cr, and UA in the saliva and the serum was calculated.
Results:In ESRD dialysis patients, the levels of Urea, Cr, and UA in the saliva and the serum were highly correlated (correlation coeffcients were 0.979, 0.973, and 0.948, respectively). The concentrations of Urea, Cr, and UA in the saliva and the serum before the dialysis were lower than those after the dialysis, with signiifcant difference (P<0.05). The RR of Urea, Cr, and UA in the saliva and the serum did not differ statistically (P>0.05).
Conclusion:The clearing effect of salivar Urea, Cr, and UA is similar to that of the serum. Saliva is expected to replace the serum to evaluate hemodialysis efficacy and monitor the renal disease in ESRD patients.
