The association of epidermal fatty acid binding protein with obesity, metabolic syndrome and cardiovascular dis-eases in children

VernacularTitle:血清上皮型脂肪酸结合蛋白与儿童肥胖、代谢综合征及其心血管危险因素的相关性研究
Author: Minglei WU ; Geli LIU ; Qingyan YANG ; Liping HAO ; Pengli BAO ; Lihong JIANG ; Rongxiu ZHENG
Publication Type:Journal Article
Keywords: child; metabolic syndrome; epidermal fatty acid binding protein; cardiovasular risk factors
From: Journal of Clinical Pediatrics 2013;(12):1117-1120
CountryChina
Language:Chinese
Abstract: Objective To study the relationship between the level of serum epithelial fatty acid binding protein (E-FABP) and cardiovascular disease in obese children. Methods Thirty children with metabolic syndrome (MS), 32 obesity children with no MS and 50 healthy children were recruited. Serum E-FABP and glucose/lipid metabolic indices were measured. Results Com-pared with the healthy children, levels of serum E-FABP in MS children were signiifcantly elevated (P=0.001). Compared with obesity children, levels of serum E-FABP of MS children were elevated, but the difference was not signiifcant (P>0.05). The cor-relations of E-FABP with waist to hip ratio, waist-to-height ratio, atherogenic index, fasting insulin, insulin resistance index were positive (P<0.05). According to the multivariate stepwise regression analysis, E-FABP was the independent risk of atherogenic index (P=0.018). Conclusions E-FABP plays a role in the development of atherosclerosis in obesity and MS.