Changes of mitochondria in human placenta in intrauterine growth restriction

VernacularTitle:线粒体在宫内生长受限胎盘中的变化
Author: Nan GU ; Xiaohui CHEN ; Xirong GUO ; Yufang QIU ; Shuping HAN
Publication Type:Journal Article
Keywords: intrauterine growth restriction; placenta; mitochondria
From: Journal of Clinical Pediatrics 2013;(12):1169-1172
CountryChina
Language:Chinese
Abstract: Objective To explore the mechanism of intrauterine growth restriction (IUGR) via observing the change of mitochondria in IUGR placenta. Methods Placenta samples were collected from 30 singleton pregnancies at the time of elec-tive caesarean section. Fifteen of them were appropriate for gestational age and 15 were IUGR. Mitochondrial morphology was observed by transmission electron microscopy, DNA copies were analyzed by real-time quantitative PCR and membrane potential was assayed by lfow cytometry. Results Signiifcant morphological changes of placental mitochondria were observed under transmission electron microscopy in IUGR, mitochondrial DNA copies in IUGR placenta were signiifcantly increased (P<0.01) and membrane potential decreased dramatically (P<0.01). Conclusions It is suggest that impaired mitochondrial function in IUGR may involve in IUGR pathogenesis.