Mechanisms of refractory Mycoplasma pneumoniae pneumonia in children
10.3969/j.issn.1000-3606.2013.12.022
- VernacularTitle:难治性肺炎支原体肺炎的发病机制
- Author:
Jinrong LIU
;
Shunying ZHAO
- Publication Type:Journal Article
- Keywords:
refractory;
Mycoplasma pneumoniae pneumonia;
mechanisms
- From:
Journal of Clinical Pediatrics
2013;(12):1186-1188
- CountryChina
- Language:Chinese
-
Abstract:
Most of Mycoplasma pneumoniae pneumonia (MPP) will be controlled after being treated with macrolide antibiotics. But in recent years refractory Mycoplasma pneumoniae pneumonia (RMPP), including severe mycoplasma pneumoniae pneumonia, are increased. RMPP often causes many severe complications and sequelae such as necrotizing pneumonia, bronchiolitis obliterans, bronchitis obliterans, atelectasis and bronchiectasis. Two main mechanisms of MPP are proposed: damages to airway directly by mycoplasma pneumonia (MP), and inflammatory reaction caused by mycoplasma pneumoniae (MP). RMPP is also associated with many other factors such as MP genotype and load, macrolide-resistant MP, airway mucus hypersecretion, hypercoagulability, combined infection with bacteria or viruses, and community acquired respiratory distress syndrome toxin (CARDS Tx). The exploration of mechanisms of RMPP helps us acquire effective treatment and prevent sequelae.
