Expression of Golgi glycoprotein 73 and secreted Clusterin in hepatocellular carcinoma

VernacularTitle:肝细胞癌组织中高尔基体糖蛋白73和分泌型聚集素的表达及其相关性分析
Author: Qian CAO ; Gulibiye SHABIER ; Ying YANG ; Lei XIAO ; Rui MAO ; Ruili ZHANG ; Hua ZHANG ; Yongxing BAO
Publication Type:Journal Article
Keywords: Hepatocellular carcinoma; Golgi glycoprotein 73; Secreted Clusterin; Invasion; Prognosis
From:China Oncology 2013;(11):880-884
CountryChina
Language:Chinese
Abstract: it was 4% (3/75). GP73-positive rate in HCC was higher than that of the normal liver tissues (χ2=73.60, P<0.05). sCLU-positive rate in HCC was also higher than that of the normal liver tissues (χ2=207.94, P<0.05). GP73 expression was positively correlated with sCLU expression in HCC (r=0.405, P<0.05). GP73 and sCLU were associated with clinicopathological features including tumor differentiation, TNM stage and vascular invasion (P<0.05); GP73 and sCLU had no correlation with the patient’s gender, age, HBsAg, cirrhosis, AFP value, portal vein thrombosis and tumor numbers (P>0.05). GP73 was associated with survival but not sCLU. Conclusion:GP73 and sCLU have higher positive rates in HCC and GP73 is positively correlated with sCLU. The expression of GP73 and sCLU are probably closely related with the invasion of HCC, which can help evaluate the prognosis of the patients.