DNA methylation and hepatocellular carcinoma
10.3760/cma.j.issn.1673-4203.2013.12.016
- VernacularTitle:DNA甲基化与肝细胞癌
- Author:
Jianyu ZHU
;
Wei WANG
;
Weidong JIA
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
DNA methylation;
Epigenetics;
Genes
- From:
International Journal of Surgery
2013;40(12):841-844
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma is one of the most common cancer with a high incidence and mortality,representing a main type of primary liver cancer.However,the molecular and cellular mechanisms of hepatocellular carcinoma pathogenesis are still poorly understood.Traditionally,the development of hepatocellular carcinoma has been viewed as a process of transforming of normal cells into malignant driven by the genetic alterations in tumor-suppressor gene deactivation and pro-oncogene activation.In recent years,with the deeper understanding of tumor,it has been found that epigenetic alterations are closely related to the occurrence and the development of hepatocellular carcinoma.DNA methylation is one of the most common epigenetic events occurring in human genome,as well as the best studied of the epigenetic changes.This review focuses on the state-of-the-art advancements of DNA methylation in hepatocellular carcinoma.
