WIF-1 and the diagnose and treatment of lung cancer
10.3760/cma.j.issn.1673-4203.2013.12.014
- VernacularTitle:WIF-1基因与肺癌的诊断和治疗
- Author:
Min GONG
;
Fei WANG
;
Zhi GAO
- Publication Type:Journal Article
- Keywords:
WIF-1 gene;
Wnt Proteins;
Lung neoplasms;
Small cell lung carcinoma;
Diagnosis;
Therapeutics
- From:
International Journal of Surgery
2013;40(12):835-837
- CountryChina
- Language:Chinese
-
Abstract:
Wingless type protein (Wnt protein) is a group of protein which plays an important role in the process of animal growth and hemopoiesis,the signaling pathway they conducted was called Wnt signaling pathway,and its abnormal activation can lead to many tumors,include lung caner.As a tumor suppressor gene,WIF-1 can restrain the activation of Wnt signaling pathway,which can avoid lung cancer.WIF-l's methylation can downregulate the expression of WIF-1,which can activate Wnt signaling pathway and cause lung cancer.So the detection of WIF-1's methylation may contribute to clinical diagnose of lung cancer,and therapy of WIF-1 's methylation may be one of the treatment metheds of lung cancer.
