Metabolism and function of intestinal microbiota from liver cirrhosis patients:a met-agenomic study
10.7644/j.issn.1674-9960.2013.11.001
- VernacularTitle:肝硬化患者肠道微生物代谢功能的宏基因组学研究
- Author:
Xiao WEI
;
Dayang ZOU
;
Xiabei YAN
;
Zhan YANG
;
Qian CUI
;
Simiao WANG
;
Liuyu HUANG
;
Jing YUAN
- Publication Type:Journal Article
- Keywords:
liver cirrhosis;
metagenomics;
glutathione;
essential amino acid;
bile acid
- From:
Military Medical Sciences
2013;(11):801-807
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the metabolism and function of the intestinal microbiota from liver cirrhosis patients.Methods Sixteen cases of liver cirrhosis and twenty normal individuals were selected , whose intestinal microbiota metagenomic DNA was extracted , followed by high-throughput Solexa sequencing and the bioinformatics analysis of metabo-lism and function annotation to compare the differences between the patients and normal subjects and find out about the cir -rhosis-related functions .Results The functional diversity was significantly reduced in the intestinal microbiota of cirrhotic patients.At the module or pathway level , the intestinal microbiota of patients showed an enrichment in metabolisms of drugs, essential amino acid , propanoate metabolism and inflammatory reaction , whereas an opposite tendency was observed in the metabolic ability of butyrate , bile acid and cell cycle .Conclusion Under the influence of liver cirrhosis , the growth environment in the intestine is destroyed , causing, the intestinal microbiota the exhibit some compensation to adapt to the changed intestinal micro-environment .
