Relationship between the density difference of microRNA binding and the evolution-ary conservation of 3′UTRs in housekeeping and non-housekeeping human genes

VernacularTitle:人类管家基因和非管家基因microRNA绑定密度的比较及与3′UTR进化保守性关系的分析
Author: Zheyan LIU ; Yiming LU ; Wubin QU ; Chenggang ZHANG
Publication Type:Journal Article
Keywords: housekeeping genes; non-housekeeping genes; microRNA; sequence-based prediction; expression profiles data; evolution analysis
From: Military Medical Sciences 2013;(11):808-813
CountryChina
Language:Chinese
Abstract: Objective To study the microRNA ( miRNA) regulation on the expression of housekeeping and non-house-keeping human genes from the systemic level , and to reveal the influence of conservation at 3′UTRs region for the density difference of miRNA regulatory between the two classes of genes .Methods We obtained miRNA regulation informations for the two classes of genes through the integration analysis of three sequence-based target gene prediction softwares and the conjoint analysis based on gene expression profile data .We also used phastCons-score based evolution analysis to study the conservation of 3′UTRs regions between the two classes of genes .Results Our results showed that housekeeping genes have a significantly higher density of miRNA binding sites and their 3′UTR are relatively conservative .Conclusion These findings highlight the importance of miRNA regulation in housekeeping genes , suggesting that investigating the roles of miR-NAs on the robustness of housekeeping genes expression is highly necessary .