Advance in research on CML therapy by gene silence and adoptive cellular immunotherapy
10.7644/j.issn.1674-9960.2013.11.018
- VernacularTitle:CML的基因沉默与过继免疫治疗的研究进展
- Author:
Binghua GAO
;
Xinsheng WANG
- Publication Type:Journal Article
- Keywords:
chronic myeloid leukemia;
immunotherapy,adoptive;
gene silencing;
RNA,smallinterfering;
miRNA
- From:
Military Medical Sciences
2013;(11):870-872
- CountryChina
- Language:Chinese
-
Abstract:
Chronic myeloid leukemia is a kind of malignant cloning hyperplastic disease of hematopoietic stem cell .The treatments based on molecular biological and immunological techniques will become the new therapies .Gene silence can improve the effects of molecular targeted therapeutic drugs through two ways: one is the target mRNA can be digested by siRNA and the other is target gene lose the stability and reduce the generation of protein mediated by miRNA .Adoptive cel-lular immunotherapy is a treatment method through injecting immunocompetent cells such as CIK , NK, etc into the body of cancerous person .This can improve the immunity of body and the effects of molecular targeted therapeutic drugs .The fur-ther study about basic theory , molecular mechanism and clinical effects will be continued .
