Study on the relationship between heme oxygenase-1 and glutathione S-transferase and cerebral atherosclerosis

VernacularTitle:血红素氧合酶-1和谷胱甘肽转移酶与脑动脉硬化程度的关系
Author: Ying ZHOU ; Zhaoyun LIU ; Ziqing GUO ; Chanjuan CHEN ; Juan CHEN
Publication Type:Journal Article
Keywords: Heme oxygenase (decyclizing)/blood; Glutathione transferase/blood; Intracranial arteriosclerosis
From: Journal of Chinese Physician 2013;15(11):1458-1461
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between heme oxygenase-1 (HO-1),glutathione S-transferase (GST) and cerebral atherosclerosis.Methods Cerebralvascular status was assessed with color flow Doppler sonography,transcranial Doppler (TCD),magnetic resonance angiography (MRA)or/and digital subtraction angiography (DSA) in patients with cerebral atherosclerosis (mild,moderate,and severity).Serum HO-1 and GST were measured with enzyme-linked immunosorbent assay (ELISA).Results In comparison between case and control groups,there was significant difference in age,hypertension,cerebral infarction,uric acid,and HO-1 (P =0.041,0.008,0.000,0.036,and 0.001).The level of serum HO-1 in the severe atherosclerosis was lower than that in the mild and moderate atherosclerosis (P =0.000 and 0.002).Logistic regression was used to find the association of HO-1 and the degree of cerebral atherosclerosis (P =0.000).Conclusions HO-1 might be related to cerebral atherosclerosis.