Genomics of breast cancer
10.3969/j.issn.1000-8179.20132011
- VernacularTitle:乳腺癌基因组学研究进展
- Author:
Bailin ZHANG
;
Fengju SONG
- Publication Type:Journal Article
- Keywords:
breast cancer;
genomics;
next-generation sequencing;
personalized medicine;
somatic mutation
- From:
Chinese Journal of Clinical Oncology
2014;(3):207-210
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer is caused by somatic mutation. As such, somatic mutation in breast cancer should be described to eluci-date the underlying mechanism. Next-generation sequencing has provided new insights into the genomics of breast cancer. New genes were identified and exhibited a relationship with breast cancer. Although these genes mutated at a low frequency, such genes in different cases could be categorized into specific pathways. Mutational signatures could be found in some cases, but such signatures were gener-ally not related to environmental exposure. Studies on intra-tumoral heterogeneity have revealed the ubiquitous presence of sub-clones in breast cancer;however, a major clone is also observed, accounting for>50%of tumor cells. Current advancements show that breast cancer genomics has been integrated into personalized medicine. Furthermore, a genome-informed and personalized molecular sub-typ-ing and treatment of breast cancer can be developed in the future.
