Research progress on tumor targeting of splice variants
10.3969/j.issn.1000-8179.20131008
- VernacularTitle:剪接变异体的肿瘤靶向性研究进展
- Author:
Yanni LI
;
Hui YAO
- Publication Type:Journal Article
- Keywords:
splice variant;
alternative splicing;
tumor-specific;
targeting
- From:
Chinese Journal of Clinical Oncology
2014;(3):215-217
- CountryChina
- Language:Chinese
-
Abstract:
Splice variants are transcripts that exhibit various functions or activities and are obtained from alternative splicing of precursor mRNA. An increasing number of tumor-specific splice variants are being discovered and their roles in cancer development and progression are being investigated. In this study, the expression patterns and activities of tumor-specific splice variants were charac-terized. The results suggest that a variant-specific gene therapy that targets cancer cells would be more specific and would have minimal effect on healthy tissues. Using antisense oligonucleotides, mRNA that contributed to cancer cell survival and altered splicing patterns was downregulated in a clinical trial. The results provide a new appreciation for the gene therapy of cancer. Identification of novel tu-mor-specific splice variants and constant improvement of therapeutic strategies by modifying splicing patterns can lead to the develop-ment of more effective and safer cancer therapies.
