The Effect of Isoflurane Anesthesia on the Succinylcholine - Induced Muscle Fasciculations in Children.
10.4097/kjae.1994.27.12.1765
- Author:
Hyeon Jeong YANG
1
;
Keon Sik KIM
;
Dong Ok KIM
;
Ok Young SHIN
;
Kwnag Il SHIN
Author Information
1. Department of Anesthesiology, College of Medicine, Kyung Hee University, Seoul, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Isoflurane;
Succinylcholine;
Fasciculstion
- MeSH:
Anesthesia*;
Arrhythmias, Cardiac;
Child*;
Fasciculation*;
Heart Rate;
Humans;
Intubation;
Isoflurane*;
Masks;
Nitrous Oxide;
Oxygen;
Succinylcholine*;
Thiopental
- From:Korean Journal of Anesthesiology
1994;27(12):1765-1770
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Forty children were anesthetized with either thiopental 5mg/kg followed by succinylcholine 1.5mg/kg I.V. or with isoflurane 3.5 vol% in 66% nitrous oxide in oxygen via a face mask followed by succinylcholine 1.5mg/kg I.V.. The study was randomized, in the thiopental group, fasciculation were seen in all children and in the isoflurane group, in 10 of 20 children(p<0.001). The intensity of the fasciculation was 1.6+/-0.7 in the thiopental group and 0.6+/-0.4 in the isoflurane group(p<0.001). The duration of fasciculstion was 35.6+/-13.6sec in the thiopental group and 9.0+/-8.0 sec in the isoflurane group(p<0.001). No cardiac arrhythmias were noted in either group, but heart rates were inereased significantly after intubation in both group(p<0.001). ln conclusion, isoflurane in nitrous oxide may inhibit succinylcholine-induced muscle fasciculation in children.
