Study on expression of stem cell marker SALL4 gene in cervical cancer
10.3969/j.issn.1671-8348.2014.03.011
- VernacularTitle:干细胞标志物SALL4在宫颈癌中的表达研究
- Author:
Ming ZHANG
;
Yiming ZHANG
;
Wei ZUO
;
Hui QIAN
;
Wenrong XU
- Publication Type:Journal Article
- Keywords:
SALL4 gene;
cervical cancer;
immunohistochemistry
- From:
Chongqing Medicine
2014;(3):285-287
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the expression and clinical significance of SALL 4 gene in cervical cancer .Methods The ex-pression of SALL4 in 56 samples of cervical cancer and 35 samples of normal cervical tissues was detected by immunohistochemistry and RT-PCR ,and its relationship with the clinicopathological characteristics of cervical cancer was analyzed .Results The expres-sion of SALL4 mRNA was 2 .56 ± 0 .22 in cervical cancer tissues ,which was significantly higher than 0 .38 ± 0 .03 in the normal cer-vical tissues .the difference between them had statistical significance(t=58 .1 ,P<0 .01);the positive expression rate of SALL4 pro-tein was 80 .4% (45/56) in cervical cancer ,which was significantly higher than 11 .4% (4/35) in the normal cervical tissues (χ2 =41 .177 ,P<0 .01) .The positive expression of SALL4 in the cervical cancer tissues was correlated with the differentiation status of tumor ,which in the middle and high differentiation groups was lower than that in the low differentiation group (χ2 =4 .226 ,P=0 .039) ,but had no correlation with age ,International Federation of Gynecology and Obstetrics (FIGO) stage ,tumor size ,pathologi-cal type and lymph node metastasis(P>0 .05) .Conclusion SALL4 is highly expressed in the cervical cancer tissues and correlated with the tumor differentiation ,which might play an important role in the occurrence and development of cervical cancer .
