Clinical outcomes of advanced gastric cancer patients treated with chemotherapy of paclitaxel liposome combined with S-1 or oxaliplatin
10.3969/j.issn.1000-8179.20131536
- VernacularTitle:替吉奥或奥沙利铂联合紫杉醇脂质体治疗进展期胃癌的临床分析
- Author:
Qingqing MA
;
Yanli QU
;
Yong TANG
- Publication Type:Journal Article
- Keywords:
stomach neoplasms;
drug therapy;
paclitaxel liposome;
S-1;
oxaliplatin
- From:
Chinese Journal of Clinical Oncology
2014;(3):200-203
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aimed to compare the efficacy and adverse reactions of two different chemotherapeutic regi-mens. In particular, chemotherapy with paclitaxel liposome was administered in combination with either S-1 or oxaliplatin as the first-line therapy of advanced gastric cancer. Methods:A total of 118 patients with advanced gastric cancer were randomly divided into groups A (61 cases) and B (57 cases). In group A, paclitaxel liposome combined with S-1 was administered;in group B, paclitaxel lipo-some combined with oxaliplatin was applied. The short-term efficacy, adverse reactions, Karnofsky performance status score, median time to progression (mTTP), and median overall survival (mOS) of the two groups were observed and compared. Results:No signifi-cant differences were observed in the objective response rate, disease control rate, and mTTP between groups A and B (31.1% vs. 29.8%, 75.4%vs. 71.9%, 4.2 months vs. 3.8 months;P>0.05). The mOS rates were 10.5 and 8.9 months in groups A and B, respectively, with statistically significant differences (P=0.006). The incidence of degreesⅢtoⅣdiarrhea and peripheral nerve toxicity was signifi-cantly higher in group B than in group A (P<0.05). No statistical differences were found between the two groups in terms of other side effects. Conclusion:The two paclitaxel liposome-based regimens showed similar therapeutic effect in patients with advanced gastric cancer. S-1/paclitaxel liposome treatment could be more effective in terms of mOS and had a tendency of lower toxicity.
