Diagnostic Utility of Osteocalcin, Undercarboxylated Osteocalcin, and Alkaline Phosphatase for Osteoporosis in Premenopausal and Postmenopausal Women.
- Author:
Sacide ATALAY
1
;
Abdullah ELCI
;
Huseyin KAYADIBI
;
Can B ONDER
;
Nurettin AKA
Author Information
- Publication Type:Original Article
- Keywords: Bone mineral density; Menopause; Osteocalcin; Osteoporosis; Undercarboxylated osteocalcin
- MeSH: Adult; Aged; Alkaline Phosphatase/*blood; Body Mass Index; Bone Density; Discriminant Analysis; Female; Follow-Up Studies; Humans; Logistic Models; Middle Aged; Osteocalcin/*blood; Osteoporosis/blood/*diagnosis; Osteoporosis, Postmenopausal/blood/diagnosis; Postmenopause; Premenopause
- From:Annals of Laboratory Medicine 2012;32(1):23-30
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: We aimed to investigate the diagnostic utility of osteocalcin (OC), undercarboxylated osteocalcin (ucOC), and alkaline phosphatase (ALP) in pre- and postmenopausal women for femoral neck, L1-4, and L2-4 bone mineral density (BMD) values by taking into consideration their age, body mass index (BMI), and menopausal status. METHODS: Premenopausal (N=40) and postmenopausal cases (N=42) were classified as 25-34 or 35-45 yr of age and within the first 5 yr or 5 yr or more after the onset of menopause, respectively. RESULTS: Among the groups, statistical differences were found for age, BMI, OC, ucOC, ALP, femoral neck BMD, L1-4 BMD, and L2-4 BMD. The highest serum OC, ucOC, and ALP levels were observed in cases within the first 5 yr after the onset of menopause, probably due to a more rapid bone turnover rate. The best predictors for the femoral neck osteoporosis were ALP, OC, and calcium (areas under the ROC curve [AUC]=0.882, 0.829, and 0.761, respectively), and those for L1-4 and L2-4 osteoporosis were OC, ALP, and ucOC (AUC=0.949, 0.873, and 0.845; and 0.866, 0.819, and 0.814, respectively). Multiple logistic regression analysis revealed that the most discriminative parameter for osteoporosis was OC. CONCLUSIONS: These results indicate that serum OC levels, with or without ucOC and ALP, may be useful to monitor follow-up changes that currently cannot be assessed with BMD and to diagnose femoral neck, L1-4 spine, and L2-4 spine osteoporosis.
