Spatial working memory in patients with deficit and nondeficit schizophrenia
10.3936/j.issn.1002-0152.2013.11.003
- VernacularTitle:首发缺陷型和非缺陷型精神分裂症患者空间工作记忆功能的对照研究
- Author:
Jian WANG
;
Wei DENG
;
Qiang WANG
;
Xiaohong MA
;
Mingli LI
;
Yuanyuan HAN
;
Yang LIU
;
Tao LI
- Publication Type:Journal Article
- Keywords:
Deficit Schizophrenia;
Spatial Working Memory (SWM);
the Cambridge Neuropsychological Test Au-tomated Battery (CANTAB)
- From:
Chinese Journal of Nervous and Mental Diseases
2013;(11):651-657
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the difference of spatial working memory among first-episode patients with deficit and nondeficit schizophrenia. Methods The study recruited 116 first-episode treatment-naive patients with schizo-phrenia, and 60 normal controls. Positive and Negative Syndrome Scale (PANSS) was used to assess symptoms of patients and Schedule for the Deficit Syndrome (SDS) was used to divide schizophrenia patients into deficit group (28 patients) and nondeficit group (88 patients). Spatial Working Memory (SWM) test from the Cambridge Neuropsychological Test Automat-ed Battery (CANTAB) was used to test the spatial working memory function. Results Adjusted for age, gender and years of education, there were significant differences in the performance of between errors of 4 boxes (P=0.03), between errors of 6 boxes (P=0.01), between errors of 8 boxes (P=0.03), total errors (P=0.01) and strategy (P<0.01) between deficit and nondef-icit patients, and both groups were poorer than the control group. The SWM of deficit and nondeficit patients has no corre-lation with the negative symptoms (P>0.05). Conclusion The impairment of SWM was more severe in deficit schizophrenia patients than in nondeficit patients at early stage of the disease, suggesting they are different subtypes of schizophrenia.
