Synergy Effect of Effective Substances Group and Mechanism of Qi-Zhi Wei-Tong Granules in Promoting Gastrointestinal Dynamic Effect
10.11842/wst.2014.01.009
- VernacularTitle:气滞胃痛颗粒促胃肠动力有效物质组分协同关系及作用机制研究
- Author:
Yaling CUI
;
Xiansheng MENG
;
Yongrui BAO
;
Shuai WANG
;
Ying PAN
;
Ling HAN
- Publication Type:Journal Article
- Keywords:
Qi-Zhi Wei-Tong Granules;
gastrointestinal motility promotion;
synergy effect;
analytic hierarchy process
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(1):52-57
- CountryChina
- Language:Chinese
-
Abstract:
This article was aimed to study the synergy effect of effective substances group and mechanisms of Qi-Zhi Wei-Tong (QZWT) Granules in promoting gastrointestinal dynamic effect in order to explore its mechanism. Rats were divided into 16 groups. Different component compatibility was given to promote the gastrointestinal dynamic ef-fect. The traditional semi-solid paste carbon propelling analysis method was used to observe gastrointestinal motility changes of rats after medication. After intragastric administration, changes of NO, cGMP and Ca2+content in gastroin-testinal tissues were observed. The results showed that fructus aurantii flavonoids and Cyperi flavonoids had the most prominent effect in promoting gastrointestinal motility in QZWT Granules (P< 0.01), which were followed by Cyperus oil and limonene (P< 0.05). Two-way interactions indicated that the combination of fructus aurantii flavonoids and limonene had prominently promoting action in gastrointestinal motility, which was followed by the combination of fructus aurantii flavonoids and Cyperus oil, Cyperi flavonoids and Cyperus oil, limonene and Cyperus oil. Each effec-tive component can reduce the NO and cGMP content in gastrointestinal tissues, and increase the Ca2+ content. It was concluded that the study defined the correlation and synergy between effective components and promoting effect of gastrointestinal motility. Mechanism of the effective component to promote gastrointestinal dynamic might be relat-ed to the reducing of NO and cGMP content in gastrointestinal tissues and increasing of Ca2+ content. This study also provided a theoretical basis for further research on quality control, compatibility and spectrum-effect correlation of gastrointestinal motility promotion medications.
