VernacularTitle:彝药“麻补”止血活性物质基础及机理研究
Author: Hongxiang YIN ; Feiyan WEN ; Hao ZHANG
Publication Type:Journal Article
Keywords: "Yi medicine ""Ma-Bu""; Paris saponin H; hemostatic activity; material basis and mechanism"
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(1):177-180
CountryChina
Language:Chinese
Abstract: This study was aimed to carry out pharmacological research on the hemostatic activity and mechanism of Yi medicine Ma-Bu (Paris polyphylla Smith var stenophylla Franch.). One kind of C27 steroidal saponin from P. polyphylla Smith var stenophylla Franch. was isolated and identified as Paris saponin H (PSH). The effect of PSH on the index of bleeding time (BT), prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen (FIB) of mice were measured. The results showed that PSH have significant hemostatic activity by shortening BT. The effect of PSH on shortening PT and APTT of mouse was not significant. However, the FIB was enhanced significantly after treatment with PSH. It was concluded that PSH had no significant promoting effect on the extrinsic coagulation pathway (ECP) or the intrinsic coagulation pathway (ICP). The enhancement of FIB may be a pathway for the effect of hemostatic activity by PSH.