Association between CyclinA2 gene 5′-UTR polymorphism and genetic susceptibility of colorectal cancer

VernacularTitle:CyclinA2基因5′-UTR多态性与结直肠癌遗传易感性的关系
Author: Qi WANG ; Jun HUANG ; Qiang QIU ; Mingwen HUANG ; Chengliang ZHOU
Publication Type:Journal Article
Keywords: colorectal cancer; CyclinA2; single nucleotide polymorphisms
From: Chongqing Medicine 2014;(1):64-66
CountryChina
Language:Chinese
Abstract: Objective To investigate the association between the rs769236 polymorphism at the 5′-UTR region of CyclinA2 gene and the susceptibility of colorectal cancer (CRC) .Methods A case-control study was carried out on the Chinese Han population , the rs769236 polymorphism of CyclinA2 were analyzed by PCR restriction fragment length polymorphism (PCR-RFLP)in 150 CRC cases and 150 healthy controls .The association between CRC risk and the SNP (rs769236) was estimated by an unconditional logis-tic regression model .Results Compared with GG wild genotype ,variant genotypes(GA+AA) carriers had a significantly increased risk of CRC[adjusted odds ratio (OR)=1 .92 ,95% confidence interval(CI)=1 .10 -3 .36] .Conclusion The current results sug-gested that the SNP(rs769236) of CyclinA2 is significantly associated with the increased risk of CRC ,the variant genotypes(GA+AA) are the independent risk factors of CRC in Chinese Han population .