Report and literature review of two cases of coma induced by beva-cizumab combined with chemotherapy

VernacularTitle:贝伐珠单抗联合化疗导致昏迷2例并文献复习
Author: Wei WANG ; Fen FENG ; Lirong ZHAO ; Xiuqiang LIN
Publication Type:Journal Article
Keywords: bevacizumab; reversible posterior leukoencephalopathy syndrome; colorectal cancer
From: Chinese Journal of Clinical Oncology 2013;(24):1563-1566
CountryChina
Language:Chinese
Abstract: Objective:The clinical features, risk factors, and outcomes of coma were analyzed in patients treated with bevacizum-ab combined with chemotherapy This study also aims to increase the awareness on the toxicity of this regimen. Methods:Two cases of coma induced by bevacizumab combined with chemotherapy were reported. Diagnosis, treatment, and relevant literature were reviewed and discussed. Results:Inadequate blood pressure (BP) control was one of the risk factors leading to coma in patients treated with this therapy. The clinical feature of these patients was reversible posterior leukoencephalopathy syndrome (RLPS). Imaging results showed no typical finding. Reinforced supportive treatment including intensive BP control showed satisfactory outcomes. Conclusion:Coma is common in patients treated with bevacizumab combined with chemotherapy. This regimen should be used cautiously in patients with a history of hypertension. BP should be monitored closely and managed promptly during the combination therapy to prevent coma. RLPS-related coma is reversible after appropriate treatment.