CD5-negative Blastoid Variant Mantle Cell Lymphoma with Complex CCND1/IGH and MYC Aberrations.
- Author:
Yoonmi SEOK
1
;
Juwon KIM
;
Jong Rak CHOI
;
Yu Ri KIM
;
Seo Jin PARK
;
Sue Jung KIM
;
Jaewoo SONG
;
Kyung A LEE
Author Information
- Publication Type:Case Reports
- Keywords: Mantle cell lymphoma; CCND1; MYC
- MeSH: Aged, 80 and over; Antigens, CD5/*metabolism; Bone Marrow/immunology/metabolism; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 3; Gene Rearrangement; Humans; Immunophenotyping; In Situ Hybridization, Fluorescence; Lymphoma, Mantle-Cell/*diagnosis/genetics/immunology; Male; Oncogene Proteins, Fusion/*genetics; Proto-Oncogene Proteins c-myc/*genetics; Translocation, Genetic
- From:Annals of Laboratory Medicine 2012;32(1):95-98
- CountryRepublic of Korea
- Language:English
- Abstract: The coexistence of CCND1/IGH and MYC rearrangements in mantle cell lymphoma (MCL) is a rare finding associated with a very poor prognosis. In this study, a patient with blastoid variant (MCL) is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient only survived for 1 month following diagnosis. Conventional cytogenetic study, FISH, and multicolor FISH (mFISH) demonstrated the involvement of the BCL1/CCND1 locus in a complex translocation, t(3;11)(q25;p15)t(11;14)(q13;q32). In addition, subclonal abnormalities in the 8q24 region, manifested as a t(8;14)(q24;q32)/MYC rearrangement, were identified. To the best of our knowledge, this is the first MCL case in Korea bearing these complex genomic aberrations.
