Influencing factor of whole-body scan imaging on radioactive io-dine treatment for lung metastases of differentiated thyroid carci-noma
10.3969/j.issn.1000-8179.20131551
- VernacularTitle:分化型甲状腺癌肺转移131I治疗后全身扫描显像影响因素分析
- Author:
Ying ZHOU
;
Wengui XU
;
Dong DAI
;
Peiyu TUO
;
Jianjing LIU
;
Hui HUANG
;
Cong ZUO
- Publication Type:Journal Article
- Keywords:
differentiated thyroid carcinoma;
lung metastasis;
131I;
whole-body scan
- From:
Chinese Journal of Clinical Oncology
2013;(24):1558-1562
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Lung metastases are common in patients with differentiated thyroid carcinoma (DTC). Post-therapeutic 131I-whole-body scan (WBS) was conventionally administered after the radioactive iodine treatment (RAI) of DTC lung metastases. This study aimed to investigate the influencing factors of WBS imaging on the RAI of DTC lung metastases. Methods:DTC patients (n=60) with lung metastases treated with 131I were retrospectively included. Before treatment, the thyroid function was assessed. Neck and chest computed tomography (CT) was performed, and WBS was inspected. Patients with lung metastases were classified into negative and positive subgroups according to the imaging of 131I WBS, and the relative influencing factors were analyzed. Results:Univariate analy-sis showed that age and chest CT imaging, which revealed pulmonary fibrosis, calcification, and patchy shadows, were related to WBS imaging. Binary variable logistic regression analysis revealed that pulmonary fibrosis (OR=0.175, P<0.001) and calcification (OR=0.088, P<0.05) went against the development of WBS. Conclusion:WBS imaging on RAI of lung metastases was not obvious in the el-derly. The fibrosis, calcification, and patchy shadows of the lung were not conducive for WBS imaging. The fibrosis and calcification of the lung were the main factors that affect WBS imaging.
