Study on Sedative and Hypnotic Effects of Different Eluents of Shuangxiatang
10.11842/wst.2013.08.007
- VernacularTitle:双夏汤不同洗脱液镇静催眠作用研究
- Author:
Wenhui PEI
;
Yikun SUN
;
Junyi ZHANG
;
Ran WANG
;
Juanjuan DUAN
;
Aixian HE
;
Guilin ZOU
;
Fang FANG
- Publication Type:Journal Article
- Keywords:
Shuangxiatang;
eluent;
spontaneous activity;
sedative and hypnotic effects
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2013;(8):1713-1716
- CountryChina
- Language:Chinese
-
Abstract:
This article was aimed to study the sedative and hypnotic effects of different eluents of Shuangxiatang (SXT). The effects of SXT water decoction, water eluent, 20%, 70% and 95% alcohol eluent on spontaneous ac-tivity and the sleeping induced by subthreshold dose of pentobarbital sodium were measured. The results showed that the SXT decoction, 20% and 95% alcohol eluent can significantly decrease the number of rearing in mice with the percentage of 78.5%, 78.3% and 62.5%, respectively. SXT water eluent and 70% alcohol eluent can significantly decrease the spontaneous activity of mice (P < 0.01), the number of rearing (P < 0.01) and grooming time (P < 0.05). SXT water decoction can significantly shorten sleep latency (P < 0.05), prolong sleep time (P <0.05), and increase rates of sleeping in mice. SXT water eluent can significantly shorten sleep latency in mice (P< 0.05), increase rates of sleeping in mice. SXT water decoction and water eluent have the sedative and hypnotic effects. And the effects are more than alcohol eluents.