Study on Sedative and Hypnotic Effects of Different Eluents of Shuangxiatang

VernacularTitle:双夏汤不同洗脱液镇静催眠作用研究
Author: Wenhui PEI ; Yikun SUN ; Junyi ZHANG ; Ran WANG ; Juanjuan DUAN ; Aixian HE ; Guilin ZOU ; Fang FANG
Publication Type:Journal Article
Keywords: Shuangxiatang; eluent; spontaneous activity; sedative and hypnotic effects
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2013;(8):1713-1716
CountryChina
Language:Chinese
Abstract: This article was aimed to study the sedative and hypnotic effects of different eluents of Shuangxiatang (SXT). The effects of SXT water decoction, water eluent, 20%, 70% and 95% alcohol eluent on spontaneous ac-tivity and the sleeping induced by subthreshold dose of pentobarbital sodium were measured. The results showed that the SXT decoction, 20% and 95% alcohol eluent can significantly decrease the number of rearing in mice with the percentage of 78.5%, 78.3% and 62.5%, respectively. SXT water eluent and 70% alcohol eluent can significantly decrease the spontaneous activity of mice (P < 0.01), the number of rearing (P < 0.01) and grooming time (P < 0.05). SXT water decoction can significantly shorten sleep latency (P < 0.05), prolong sleep time (P <0.05), and increase rates of sleeping in mice. SXT water eluent can significantly shorten sleep latency in mice (P< 0.05), increase rates of sleeping in mice. SXT water decoction and water eluent have the sedative and hypnotic effects. And the effects are more than alcohol eluents.