Influence of Catalpol on Real-Time Gait Analysis of Cerebral Ischemia in Rats
10.11842/wst.2013.08.001
- VernacularTitle:梓醇对永久性脑缺血大鼠恢复早期实时步态的影响
- Author:
Shengwei ZHANG
;
Shifen DONG
;
Ting WU
;
Jianning SUN
- Publication Type:Journal Article
- Keywords:
Catalpol;
real-time gait behavior;
cerebral ischemia;
pMCAO rat
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2013;(8):1676-1681
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to observe the influence of Catalpol on real-time gait analysis of early recovery after permanent middle cerebral artery occlusion (pMCAO) in rats to evaluate its effect on the improvement after cerebral ischemia. Rats were randomly divided into 6 groups, which were the normal control group, model group, Tianbaoning group, Catalpol 15, 30, 60 mg·kg-1 group. Rats were trained on the gait instrument for 7 days before pMCAO, 3 times/day. After the training, pMCAO model was made. And continuous infusion was performed from the 3rd to the 14th day after the operation. Then, the real-time gait behavior was detected on the 14th day. The re-sults showed that 14 days after the surgery, compared with the normal control group, the models had a significant extending in the duty cycle (P < 0.01), and obvious increasing of the average body angle of absolute value (P <0.05), the shortening of the two feet supporting time (P < 0.05), and extending of three feet supporting time (P <0.01), and increasing of the coordination index (P < 0.01). Compared with the model group, the Catalpol of 30 mg·kg-1 and 60 mg·kg-1 group has obviously decreased duty cycle and average body angle of absolute value (P <0.05, or P < 0.01). The Catalpol of 30 mg·kg-1 can obviously reduce the coordination index of the right front foot relative to the other three feet (P < 0.05), which improved the coordination of cerebral ischemia animals. It was concluded that Catalpol can improve the real-time gait behavior changes of cerebral ischemia model rats. There-fore, Catalpol have a neural protective effect on cerebral ischemia.
