Effect of Qiju Runmu Tie on Experimental Dry Eye Syndrome in Rats
10.11842/wst.2013.08.004
- VernacularTitle:杞菊润目贴对实验性大鼠干眼症的作用研究
- Author:
Fang FANG
;
Shuofeng ZHANG
;
Zhanhong JIA
;
Qiuxia ZHANG
;
Jun WANG
;
Juanjuan DUAN
;
Guilin ZOU
;
Aixian HE
;
Jianning SUN
- Publication Type:Journal Article
- Keywords:
Qiju Runmu Tie;
dry eye syndrome;
bleomycin hydrochloride;
rat
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2013;(8):1695-1699
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to observe the improvement of Qiju Runmu Tie (QRT) on experimental dry eye syndrome in rats. The fourth day after the bleomycin hydrochloride (8 g·mL-1) was injected into the intraorbital lacrimal gland (0.06 mL) and extraorbital lacrimal gland (0.12 mL), QRT of large, medium, and small dosage (0.276 g·mL-1, 0.138 g·mL-1, 0.069 g·mL-1) was applied on rat's eyes continuously for 10 days, once a day, 1 hour every time. Rats in the control group and model group were applied with a patch containing distilled water in the same operation. The tear secretions, time of tear film break-up and pathological changes of lacrimal gland were observed from the eleventh day to the thirteenth day after injection. The results showed that compared with the control group, bleomycin hydrochloride can induce atrophy of lacrimal gland, hyperplasia and decrease bubbly mucus in the acinar lumina, significant reduce of tear secretion, and significant shorten the time of tear film break-up. Compared with the model group, QRT can significantly increase the amount of tear secretion (P <0.05), extend the tear film break-up time (P < 0.01). And the medium dosage of QRT can obviously reduce lacrimal gland tissue injury. It was concluded that external application of QRT can improve symptoms of experi-mental dry eye syndrome in rats.
