Research Progress on Understanding Relationship between Neuropeptides and Irritable Bowel Syndrome

VernacularTitle:脑肠肽与肠易激综合征相关性研究进展
Author: Ruirui SHI ; Jing WANG
Publication Type:Journal Article
Keywords: Irritable bowel syndrome; neuropeptides; research progress
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2013;(8):1747-1750
CountryChina
Language:Chinese
Abstract: The pathogenesis of irritable bowel syndrome(IBS) has not been fully elucidated. Abnormal gastrointesti-nal dynamics and visceral hypersensitivity were its main pathophysiological basis. Abnormal expression of neu-ropeptides can affect the visceral sensation, secretion and movement, leading to the occurrence of IBS. This article reviewed the relationship between neuropeptides and IBS from the following neuropeptides: 5-hydroxytryptamine (5-HT), corticotropin releasing factor (CRF), vasoactive intestinal peptide (VIP), substance P (SP), and somatostatin (SS). It provided reference evidences for the elucidation of IBS pathogenesis.