Study on Multicomponent In Vivo Releasing Rules of Zuojin Gastric Floating Sustained-release Tablet

VernacularTitle:左金胃漂浮缓释片多组分体内释放研究
Author: Song YANG ; Wen LIU ; Daye CHEN ; Xiaowei SHI ; Qun WANG ; Ying SONG
Publication Type:Journal Article
Keywords: Fingerprint; Zuoj in Gastric Floating Sustained-release Tablet; multicomponent; in v iv o releasing
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2013;(8):1796-1800
CountryChina
Language:Chinese
Abstract: This article was aimed to study the multicomponent in vivo releasing rules of Zuojin Gastric Floating Sus-tained-release Tablet. Stomach contents of rabbits were collected at different times and then prepared into solutions for the study. The HPLC was used to establish fingerprints of each time and fingerprints of completely dissolved samples. The in vivo releasing rates were calculated. The evaluation was made on releasing behaviors among index components as well as between index components and preparations. The results showed that within 10 h, the f2 of berberine and limonin, rutaecarpine, preparation were 52, 61.5, 66.4, respectively. The f2 of limonin and rutae-carpine, preparation were 70, 46.5, 53.7, respectively. It was concluded that within 10 h, the releasing behavior of berberine and limonin, rutaecarpine, preparation was similar. The releasing behavior of rutaecarpine and limonin, preparation was similar. However, the releasing behavior of limonin and preparation was different.