"Experimental Study of Six Testacean TCM""Endometriosis""Role on Goiter Model Rats"
- VernacularTitle:6种介类中药对大鼠甲状腺肿大模型影响的实验研究
- Author:
Qianqian PENG
;
Yin HONG
;
Guanghui LIAO
- Publication Type:Journal Article
- Keywords:
testacean TCM;
goiter;
rats
- From:
Journal of Zhejiang Chinese Medical University
2013;(12):1429-1432
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To observe the effects of Oysters, Abalone shel , Concha arcae, Mother-of-pearl, Concha cypraeae, Clamshel , these six testacean TCM on the goiter rats. [Method] 72 healthy SD rats were randomly divided into nine groups:normal group, model group, positive group and six testacean TCM groups. Rats were given daily propylthiouracil (0.15 g·kg-1), continuous modeling for 10d, weighing thyroid wet weight,assaying T3, T4 and TSH contents in serum by ELISA, observing the morphological changes of thyroid under light microscope. [Result] Rats in the model group compared with normal group in-creased the relative weight of thyroid, reduced the content of T3,T4, and there was a significant difference( P<0.01), thyroid fol icular epithelial cellhyperplasia was obvious;compared with the model group, Oysters and Clamshel group made the content of T3,T4 in rat rebound, and there was a significant difference (P<0.05);Oyster and Clamshel group’s thyroid fol icular cellhyperplasia were not obvious, while the hyperplasia had different levels for the other 4 kinds of testacean TCM. [Conclusion] Oysters and Clamshel were better to improve the thyroid function of the goiter model rats.
