The Clinical Significance of the Quantitative Detection of DNA of Chronic Hepatitis B Virus
- VernacularTitle:慢性乙型肝炎病毒DNA定量检测与慢性乙肝、肝脏损伤程度、HBeAg关系的探究
- Author:
Shuixian YANG
- Publication Type:Journal Article
- Keywords:
chronic hepatitis B;
hepatitis B virus;
Deoxyribonucleic acid (DNA);
ALT;
HBeAg
- From:
Journal of Zhejiang Chinese Medical University
2013;(12):1424-1425
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To explore the clinical significance of quantitative detection of hepatitis B patients with chronic hepatitis B virus DNA(HBV DNA). [Method] To select 107 cases of chronic hepatitis B patients as the research object in May 2010~March 2013 in our hospital, respectively by using fluores-cence quantitative polymerase chain reaction(FQ-PCR), enzyme-linked immunosorbent assay(ELISA) and rate method to determine the HBV DNA,the hepatitis B virus e antigen(HBeAg) and alanine aminotransferase(ALT) of al the research object. [Results] (1)To compare with mild, moderate and severe chronic hepatitis B patients with HBV DNA level, there was no statistical significance in the difference.(2)Patients with chronic hepatitis B had no correlation between HBV DNA levels and ALT levels. (3) HBeAg positive group of patients with HBV DNA level was significantly higher than that of HBeAg negative patients;to compare the two groups, there was statistical y significant difference. [Conclusion] The severity of patients with chronic hepatitis B and liver celldamage degree have no obvious relationship with HBV DNA level, but the existence of HBeAg and HBV DNA in serum levels have a close relationship, and in the process of clinical diagnosis and treatment of chronic hepatitis B patients, we should consider several factors.
