Application value of galectin-3 in the diagnosis and prognosis of heart failure

VernacularTitle:半乳糖凝集素-3在心力衰竭诊断及预后中的应用价值
Author: Dongwei PAN
Publication Type:Journal Article
Keywords: Galectin 3; Heart failure; Inflammatory factors; Diagnostic value
From: Chinese Journal of Postgraduates of Medicine 2013;36(34):43-44
CountryChina
Language:Chinese
Abstract: Objective To evaluate the value of galectin-3 (Gal-3) in the diagnosis and prognosis of heart failure.Methods Sixty-eight patients with heart failure (heart failure group) and 68 healthy person (control group) were selected.The level of Gal-3 and the incidence of cardiovascular event after 6 months follow-up was compared between two groups and among different cardiac functional grading.Results The level of Gal-3 was (44.57 ± 10.42) ng/L in heart failure group,(33.76 ± 8.18) ng/L in control group,and there was significant difference between two groups (P ＜ 0.01).The level of Gal-3 and the incidence of cardiovascular event after 6 months follow-up in cardiac functional grading Ⅳ (15 cases) was higher than that in cardiac functional grading H (32 cases),Ⅲ (21 cases)[(46.45 ± 12.21) ng/L vs.(38.47 ±9.38),(42.31 ± 10.23) ng/L,8/15 vs.9.4％(3/32),28.6％(6/21)],and there was significant difference (P ＜0.01).Conclusion As the marker of heart failure,the Gal-3 has significantly clinical value on diagnosis and prognosis to segment heart failure.