Danger factor analysis of malignant tumors after kidney transplantation

VernacularTitle:肾移植术后并发恶性肿瘤的危险因素分析
Author: Yu FAN ; Yeyong QIAN ; Bingyi SHI
Publication Type:Journal Article
Keywords: Kidney transplantation; Neoplasms
From: Chinese Journal of Organ Transplantation 2013;34(12):728-732
CountryChina
Language:Chinese
Abstract: Objective To study the incidence of malignant tumors in renal allografts and explore the mechanism of increased incidence.Method A retrospective study was performed on 1814 renal allografts under immunosuppression from 1998-2010.Result Twenty-nine cases of malignant tumors were found in 1814 cases undergoing renal transplantation with the incidence being 1.60％.Among these cases,the incidence of urinary system tumor was 72.4％,that of hepatoma carcinoma was 10.3％,that of lung cancer was 6.9％,and each of lymphoma,cutaneous cancer or nasppharyngeal carcinoma was 3.4％.Most patients accepted operations,additional therapies including chemical or radiological and immunological therapies.Conclusion The incidence of malignant tumors in renal allografts was higher than normal persons.Besides the outcome of immunosuppression,the effects of transplantation itself and primary disease before transplantation,for instance,the higher incidence of uroepithelium malignancy was frequently associated with history of long term medications.