Efficacy of hCG and hMG on testicular morphology and function in male patients with multiple pituitary hormone deficiency

Lin Tang; Guimei LI; Qian Wang

Return

Efficacy of hCG and hMG on testicular morphology and function in male patients with multiple pituitary hormone deficiency

VernacularTitle:促性腺激素治疗对多种垂体激素缺乏症男性患者睾丸形态和功能影响的时效性
Author: Lin TANG ; Guimei LI ; Qian WANG
Publication Type:Journal Article
Keywords: gonadotropin; sexual development; sex hormone; testicle; male
From: Journal of Clinical Pediatrics 2014;(2):151-155
CountryChina
Language:Chinese
Abstract: Objectives To study the impact of initial age of treatment on testicular morphology and function in male pa-tients with multiple pituitary hormone deficiency using human chorionic gonadotropin (hCG) and human menopausal gonadotro-pin (hMG). Methods Patients with multiple pituitary hormone deficiency were treated with hCG and hMG while keeping other hormone levels normal. Correlations among their testicular volume, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and height, bone age were analyzed. Results After 6-month hCG and hMG treatment, the penis length of 54 male patients was significantly increased from (2.58 ± 0.69) cm to (4.19 ± 0.77) cm , and penis circumference was also increased from (3.71 ± 1.36) cm to (5.95 ± 1.26) cm;the testicular volume was increased from (1.76 ± 1.49) ml to (5.20±2.30) ml;height was increased from (147.01 ± 12.29) cm to (151.98 ± 11.52) cm and bone age was increased from (11.22 ± 2.71) years to (11.64 ± 2.72) years;the differences before and after treatment were statistically significant (all P<0.01). As the patients' age increased, their testicular volume and testosterone level increased slowly, and significant differences amongst each age group were found (P<0.05). The in-creased value of testicular volume, serum FSH and LH levels, and height growth tended to be negatively correlated to the initial age of therapy (r=-0.517~-0.334, P<0.05). Conclusions Early and proper treatment in male patients with multiple pituitary hormone deficiency using hCG and hMG improves testicular function and secondary sex characteristics.