Influence of IL-17 on mesangial cell and its molecular mechanism
10.3969/j.issn.1000-3606.2014.02.018
- VernacularTitle:白细胞介素-17对系膜细胞功能的影响及其分子机制
- Author:
Li WANG
;
Qiu LI
;
Cuicui LI
;
Haiping YANG
;
Lijia WANG
;
Wei LIU
- Publication Type:Journal Article
- Keywords:
interleukine-17;
mesengial cell;
interleukine-1β;
transcription factor-κB
- From:
Journal of Clinical Pediatrics
2014;(2):178-182
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To investigate the effect of IL-17 on proliferation and secretion of IL-1βin the human mesangial cell line (HMCL) and explore the molecular mechanism. Methods The proliferation of HMCL induced by IL-17 was detected by MTT, the secretion of IL-1βin HMCL was measured by ELISA and the expression of NF-κB was detected by immunocyto-chemistry. Results IL-17 did not impact HMCL proliferation (P>0.05) but dose-and time-dependently promoted the secretion of IL-1β(P<0.05). And the expression of NF-κB induced by IL-17 increased comparing to that in the control group (P<0.05). Con-clusions IL-17 may induce HMCL to secrete IL-1βvia NF-κB pathway that results in kidney injury.
