A case of blindness caused by nephritic syndrome with cerebral venous sinus thrombosis
10.3969/j.issn.1000-3606.2014.02.014
- VernacularTitle:肾病综合征合并颅内静脉窦血栓致失明1例报告
- Author:
Tao SUN
;
Zhengkun XIA
;
Zhongmin FAN
;
Zhuo SHI
;
Yuanfu GAO
- Publication Type:Journal Article
- Keywords:
nephrotic syndrome;
cerebral venous sinus thrombosis;
anticoagulant therapy;
child
- From:
Journal of Clinical Pediatrics
2014;(2):160-163
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To explore the clinical manifestations, treatment and prognosis of a case of blindness caused by nephrotic syndrome with cerebral venous sinus thrombosis (CVST). Methods The clinical manifestations, diagnosis and treatment of a case of NS with CVST were analyzed. The latest domestic and foreign reseach progresses in treatment for CVST in children were reviewed. Results Epilepsy suddenly appeared with diplopia, binocular vision loss and blindness in anticoagulant therapy for the child with NS. Brain magnetic resonance venography (MRV) suggested CVST. MRV reexam-ined showed that the intracranial thrombosis was completely dissolved after urokinase thrombolysis for one month followed by ineffective heparin anticoagulation. At present, international standards of anticoagulant therapy have been adopted in the treatment for CVST patients. Coagulation function (e.g.APTT) and international standardization ratio were monitored in order to prevent bleeding. Conclusions It is better to perform neural imaging examination early in suspected CVST patients. Anti-coagulation and thrombolytic therapy should be given immediately once the risk of bleeding was excluded and used for 3-6 months.
