Significance of EGFR, Her-2 and VEGF expressions in cervical intraepithelial neoplasia and squamous cell carcinoma
10.3760/cma.j.issn.1006-9801.2013.11.008
- VernacularTitle:表皮生长因子受体、Her-2、血管内皮生长因子在子宫颈上皮内瘤变和鳞状细胞癌中的表达及意义
- Author:
Li GENG
;
Yu DENG
;
Zhongqiu WANG
- Publication Type:Journal Article
- Keywords:
Receptor,epidermal growen factor;
Her-2;
Vascular endothelial growth factor;
Cervical intraepithelial neoplasia;
Uterine cervical neoplasms
- From:
Cancer Research and Clinic
2013;25(11):750-753
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of EGFR,Her-2 and VEGF in cervical intraepithelial neoplasia (CIN) and cervical squamous cell carcinoma,as well as its clinic value of carcinogenesis,progression and metastasis in ccrvical squamous cell carcinoma.Methods EGFR,Her-2 and VEGF were evaluated by immunohistochemistry in tissues from normal cervix,CIN and squamous cell carcinoma.Results The expressions of EGFR,Her-2 and VEGF were negative in normal cervix.The positive rate of EGFR,Her-2 and VEGF in CIN tissues were 35.0 ％ (14/40),37.5 ％ (15/40),42.5 ％ (17/40),while in cervical carcinoma tissues were 70.0 ％ (35/50),78.0 ％ (39/50),76.0 ％ (38/50) respectively,which had statistical significance.There was relationship between the expressions of EGFR,Her-2,VEGF proteins with pathological grade andlymph node metastasis of squamous cell carcinoma.The expressions of Her-2 and VEGF correlated with the clinical stage of quamous cell carcinoma.Conclusion The expressions of EGFR,Her-2 and VEGF may be correlated with the occurrence,development and metastasis of cervical carcinoma.It may be used as an important marker to evaluate the malignant degree of cervical carcinoma and it can be helpful in the treatment of cervical carcinoma.
