Research progress of mesenchymal stem cell-antitumor gene complexes in cancer treatment

VernacularTitle:间充质干细胞-抗肿瘤基因复合物治疗肿瘤的研究进展
Author: Lei DAI
Publication Type:Journal Article
Keywords: Neoplasms; Mesenchymal stem cell; Homing; Tumor suppressor gene; Tumor necrosis factor-related apoptosis inducing ligand
From: Cancer Research and Clinic 2013;25(11):788-791
CountryChina
Language:Chinese
Abstract: Mesenchymal stem cell (MSC) possesses highly self-renewal properties and potential ability of multiple differentiations.The homing and directional migration of MSC to tumors makes MSC uniquely destined as a potential anti-tumor gene carrier.MSC itself is discovered involved in remodeling the tumor microenvironment and regulating the biological behaviors of tumor cells such as invasion,proliferation and migration.Anti-tumor genes,such as tumor necrosis factor-related apoptosisinducing ligand (TRAIL) and phosphatase and tensin homologue deleted on chromosome 10 (PTEN) combine MSC to constitute a complex dually targeting tumor cells for destruction,but no damage to normal tissue.However,many questions remain to be answered and the precise mechanisms remain unclear.In this article,the current situation and prospects of the homing mechanism of MSC,the effects of MSC to tumor biological behavior and MSC-antitumor gene complex for tumor therapy are reviewed.