Comparison of the effects of placental growth factor and vascular endothelial growth factor on acute myocardial infarction
10.3760/cma.j.issn.1001-4497.2013.12.012
- VernacularTitle:VEGF和PLGF对大鼠急性心肌梗死后左心室重构及心功能的影响
- Author:
Wang LYU
;
Hui PAN
;
Yiqing WANG
;
Weidong LI
;
Yu ZOU
;
Chong ZHANG
;
Tao JIN
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Vascular endothelial growth factors;
Ventricular remodeling;
PLGF
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2013;29(12):747-751
- CountryChina
- Language:Chinese
-
Abstract:
Objective AMI is a prevalent global health condition.This study assessed the effects of PLGF and VEGF in a rat model of post-AMI.Methods Wistar rats underwent LAD ligation and injection of VEGF,PLGF,VEGF + PLGF,antiVEGFR1,anti-VEGFR2,anti-VEGFR1 + anti-VEGFR2,IgG2α,or saline,into the infarct border zone.We also set up a pseudo-operation group.Two weeks later,heart function was detected by hemodynamic and geometry,then the hearts were dis sected and HE stained.We assessed vW factor and α-SMA by immunohistochemistry and cardiomyocyte apoptosis rate by TUNEL.Results Rats in the VEGF + PLGF group performed significantly well in cardiac function,had weaker LV remodeling and less cardiomyocyte apoptosis.There were no obvious changes in VEGF group.The use of VEGFR1/VEGFR2 antibody didnt deteriorate the rat's cardiac function.More new-born arteries were seen in PLGF and VEGF + PLGF rats,and change wasnt found in other groups.Lastly,the most angiogenesis,the least left ventricular remodeling and the best heart function were observed in VEGF + PLGF group.Conclusion Earlier intervention with PLGF or VEGF + PLGF can improve heart function in rats with AMI; VEGF alone didnt improve heart function.VEGFR1/VEGFR2 antibody didnt aggravate the rat's heart function.This indicates that left ventricular and coronary remodeling may involve other factors.
