Effects of exclusive enteral nutrition on the mucosal healing in adult patients with active Crohn's disease
10.3760/cma.j.issn.0254-1432.2013.12.011
- VernacularTitle:全肠内营养对成人活动期克罗恩病患者黏膜愈合效果的研究
- Author:
Zhen GUO
;
Weiming ZHU
;
Jianfeng GONG
;
Wei ZHANG
;
Zhiming WANG
;
Ning LI
;
Jieshou LI
- Publication Type:Journal Article
- Keywords:
Crohn disease;
Enteral nutrition;
Intestinal mucosa;
Colitis,ulcerative;
Endoscopy
- From:
Chinese Journal of Digestion
2013;33(12):831-834
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of exclusive enteral nutrition (EEN) on the mucosal healing under endoscopy in adults with active Crohn's disease (CD).Methods From August 2011 to August 2012,adults with active CD met the inclusion criteria were prospectively enrolled and treated with EEN for four weeks.CD activity index(CDAI) score,C-reactive protein (CRP) were evaluated once enrolled and by the end of the second and fourth week.Colonoscopy or small intestinal endoscopy examination was conducted once enrolled and by the end of fourth week,and CD simplified endoscopic score (SES-CD) was also caculated.Wilcoxon test was applied to compare the efficacy.Results Eight patients met inclusion criteria and finished the study.Seven cases achieved clinical remission.Compared with those before treatment,both CDAI score and CRP level decreased significantly after treatment (both Z=2.52,both P=0.012).After treatment,two patients achieved mucosal healing and the mucosa of six cases improved.The mucosa healing rate and improvement rate of terminal ileum was higher than that of colon (3/8 vs 1/6; 5/8 vs 3/6).Compared with those before treatment,SES-CD total score and SES-CD score of ileum decreased significantly after treatment (Z=2.23,2.07; P=0.026,0.038).There was no significant difference in SES-CD score of colon before and after treatment (P =0.102).Conclusions EEN could induce clinical remission in adults with active CD,and promote the healing of mucosal ulcer under endoscopy.The healing rate of colon was lower than that of small intestine.
