Changes of serum leptin levels and the influential factors in peritoneal dialysis patients
10.3760/cma.j.issn.1001-7097.2013.12.005
- VernacularTitle:腹膜透析患者血清瘦素水平的变化及影响因素分析
- Author:
Huanqing YAN
;
Yun LI
;
Qionghong XIE
;
Yi MO
;
Tongying ZHU
- Publication Type:Journal Article
- Keywords:
Peritoneal dialysis;
Lipid metabolism disorder;
Leptin;
Insulin resistance
- From:
Chinese Journal of Nephrology
2013;29(12):898-901
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of serum leptin levels and the influential factors in maintenance peritoneal dialysis patients.Methods Seventy-six peritoneal dialysis patients were chosen at the time before,and 3 months,6 months,12 months,18 months and 24 months after they began the peritoneal dialysis therapy,to examine body mass index (BMI),triceps skinfold thickness (TSF),abdominal circumference,homeostasis model assessment of insulin resistance (HOMA-IR),the plasma lipid profile,and leptin in the same situation.Results For 24 months,these patients showed higher serum leptin level than the values before commencing peritoneal dialysis treatment (P ＜ 0.01).The level of leptin was positively correlated with the BMI(r =0.412,P ＜ 0.01),TSF(r =0.308,P ＜ 0.01),abdominal circumference(r =0.284,P ＜ 0.01),HOMA-IR(r =0.184,P ＜ 0.01) and TG(r =0.288,P ＜ 0.01),negatively corelated with the high-density lipoprotein cholesterol(HDL-C)(r =-0.285,P ＜ 0.01).Multiple logistic regression analysis showed that BMI (β =0.339,P ＜ 0.01),TGβ =0.157,P ＜ 0.01) and HDL (β =-0.126,P ＜ 0.05)were significant predictive factors for the changes of serum leptin levels.Conclusion Leptin maybe involve in the occurrence and the development of cardiovascular events like other metabolic parameters in peritoneal dialysis therapy.
