Association between endothelial dysfunction and arterial stiffness in continuous ambulatory peritoneal dialysis patients
10.3760/cma.j.issn.1001-7097.2013.12.004
- VernacularTitle:连续不卧床腹膜透析患者内皮功能障碍与动脉僵硬度的关系
- Author:
Yue GU
;
Lei YAN
;
Xiaoguang FAN
;
Pan HE
;
Qing ZHU
;
Fengmin SHAO
- Publication Type:Journal Article
- Keywords:
Peritoneal dialysis;
Cardiovascular diseases;
Endothelium,vascular;
Arterial stiffness
- From:
Chinese Journal of Nephrology
2013;29(12):893-897
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between endothelial dysfunction and arterial stiffness in continuous ambulatory peritoneal dialysis (CAPD) patients.Methods Ninetyfour stable CAPD patients from a single center were enrolled in this cross-sectional study.Ultrasound evaluation was conducted on brachial artery to estimate endothelial-dependent flow-mediated dilation (FMD).Automatice pulse wave velocity (PWV) measuring system was applied to examine the carotidfemoral PWV.Blood pressure and biochemical parameters were detected.Pearson's correlation and Stepwise multiple regression analysis were performed to explore the relationship between FMD and PWV.Results PWV was significantly higher in patients with diabetes as compared to those without diabetes[(13.25± 1.66) m/s vs (11.24±1.92) m/s,P ＜ 0.01].Furthermore,PWV was positively correlated with age(r=0.319,P=0.002),SBP (r=0.289,P=0.005) and C-reactive protein (r=0.211,P=0.041),was negatively correlated with albumin (r =-0.429,P =0.001) and FMD (r=-0.466,P=0.001).In multivariate regression analysis,diabetes mellitus,albumin,FMD,age and SBP were independently associated with PWV after adjustment.Conclusion Endothelial dysfunction is associated with greater arterial stiffness in CAPD patients.
