Effects of laparoscopic radical gastrectomy on gut barrier function

VernacularTitle:腹腔镜胃癌根治术对肠道屏障功能的影响
Author: Long HAO ; Xiaoming HONG ; Hongcun SHA
Publication Type:Journal Article
Keywords: Stomach neoplasms; Laparoscoies; Gastrectomy; Gut barrier function
From: Chinese Journal of General Surgery 2013;28(12):938-940
CountryChina
Language:Chinese
Abstract: Objective To study the influence of laparoscopic gastric surgery on the gut barrier function (GBF).Methods There were 64 gastric cancer patients undergoing respectively laparoscopic radical procedures (32 cases) and open gastric surgery (32 cases).Blood was drawn on day one before surgery,day 1,day 3 and day 7 after the surgery for the measurement of plasma D-lacate and plasma diamine oxidase activity by using ultraviolet spectrophotometry.Results There was no statistical difference among demographic,clinicopathological characterastics between the two groups (P ＞ 0.05).The difference on the operative time,blood loss and the time starting to take food after the surgery was significant between the two groups,P ＜ 0.05.The differences of plasma D-lacate level and the diamine oxidase (DAO) on perioperatively respective all time points were not significant between the two groups,P ＞ 0.05.Conclusion Laparoscopic radical gastrectomy is comparable to open procedures in causing damage to patient's gut barrier functions.