The use of 5-hydroxytryptamine (5HT) receptor antagonist after percutaneous transluminal angioplasty in infrapopliteal arteriosclerotic occlusive disease
10.3760/cma.j.issn.1007-631X.2013.11.017
- VernacularTitle:盐酸沙格雷脂在膝下动脉硬化闭塞腔内治疗术后下肢缺血中的作用
- Author:
Chunli YU
;
Lubo MA
;
Tong ZHANG
;
Miao YANG
;
Bo SHI
;
Baixi ZHUANG
- Publication Type:Journal Article
- Keywords:
Arteriosclerosis obliterans;
Chemotherapy,adjuvant;
Angioplasty;
Serotonin antagonists
- From:
Chinese Journal of General Surgery
2013;28(11):871-873
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate a 5HT receptor antagonist sarpogrelate hydrochloride after percutaneous transluminal angioplasty (PTA) in infrapopliteal arteriosclerotic occlusive disease.Methods From June 2010 to June 2012,105 (116 limbs) patients of infrapopliteal arteriosclerosis obliterans treated by PTA were divided randomly into two groups:treatment group (58 cases,64 limbs)and control group(47 cases,52 limbs).All patients were treated with aspirin and clopidogrel for 3 months.Patients in treatment group were treated with additional sarpogrelate hydrochloride.Intermittent claudication,rest pain,amputation rate,ABI,vascular prosthesis obstructing degree were assessed.Results 95 patients were followed up for 6 months,the intermittent claudication rate in treatment group and control group were 3.8％ and 16.3％ (P ＜ 0.05); while there was not different on 1,3 months,in the intermittent claudication rate and 1,3,6 months,in rest pain rate,amputation rate,target artery patency rate and ABI between the two groups (P ＞ 0.05).There was one bleeding event in treatment group (1.7％).Conclusions 5HT receptor antagonist (sarpogrelate hydrochloride) significantly improves intermittent claudication after PTA in infrapopliteal arteriosclerotic occlusive disease,and its use is safe with aspirin and clopidogrel.
