The impact of hepatitis B virus infection on patients outcome following resection for intrahepatic cholangiocarcinoma

VernacularTitle:乙肝病毒感染对肝内胆管细胞癌术后患者生存的影响
Author: Ruiqing LIU ; Shujing SHEN ; Xiufeng HU ; Xingya LI
Publication Type:Journal Article
Keywords: Bile duct neoplasms; Hepatitis B,chronic; Survival rate
From: Chinese Journal of General Surgery 2013;28(11):846-849
CountryChina
Language:Chinese
Abstract: Objective To evaluate the impact of chronic hepatitis B virus (HBV) infection on the outcome following resection for intrahepatic cholangiocarcinoma (ICC) patients.Methods The clinicpathological data of 60 consecutive operated ICC patients were collected.These patients were divided into group A with HBV infection,represented by serum positive hepatitis B surface antigen (HBsAg),group B with hepatitis B surface antibody (HBsAb) positive,and group C with all serum marker of HBV negative.The overall survival rate was evaluated.Results The 1-and 3-year overall survival rate and median survival of three groups were 50％ vs 53％ vs 29％ ; 22％ vs 18％ vs O; and 12.0 m vs 12.0 m vs 6 m,respectively.The difference was statistically significant(P =0.037).Multivariate analyses revealed that the preoperative serum level of TIBL,tumor location,HBV infection or injection of hepatitis B vaccine,hepatolithiasis and adjuvant chemotherapy were related to the prognosis.Conclusions HBV infection or injection of hepatitis B vaccine is favorable independent factor for prognosis of patients with intrahepatic cholangiocarcinoma after resection.