Immunohistochemical study on sweat gland tumors.
- Author:
Kyung Jeh SUNG
;
Kwang Hyun CHO
;
Hong Keun CHUNG
;
Sung Bum KIM
;
Jee Ho CHOI
;
Jai Kyoung KOH
- Publication Type:Original Article
- Keywords:
Immunohistochemical staining;
Sweat gland tumor
- MeSH:
Acrospiroma;
Adenoma;
Antibodies;
Apocrine Glands;
Carcinoma, Adenoid Cystic;
Coloring Agents;
Eccrine Porocarcinoma;
Immunoenzyme Techniques;
Keratins;
Poroma;
S100 Proteins;
Skin;
Sweat Glands*;
Sweat*;
Syringoma
- From:Korean Journal of Dermatology
1992;30(3):303-316
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The histogenesis and differentiation of sweat gland tumors are controversial. Twenty-two cases of sweat gland tumors were stained by immunoperoxidase technique (ABC method) for the presence of S-100 protein, CEA, and two kinds of keratin. Four syringomas, 4 eccrine poromas, 2 eccrine porocarcinomas, 2 eccrine spiradenomas, 1 papillary eccrine adenoma, 3 clear cell hidradenomas, 3 mixed tumors of skin, 2 papillary syringocystadenomas, and 1 cylindroma were included. All samples were formalin-fixed and paraffin-erribedded. Two monoclonal cytokeratin ant.ibodies, MA-902 (specific for cytokeratin No. 8) and MA-903 (specific for cytokeratins No.1,5,10,11) were used. In normal eccrine and apocrine glands, MA-902 stains cells of the intradermal duct and secretory portion. While MA-903 stains cells of the intraepidermal and intradermal duct and myoepithelial cells of eccine and apocrine glands, S-100 protein is found in the secretory cells of the intradermalduct and secretory portion, while CEA stains the secretory and ductal cells of eccrine and apocrine glands. All sweat gland tumors we studied stained by 4 antibodies in variable positive rates, Based on these findings, we discuss the histogenesis of various sweat gland tumors.
