The effect of a biodegradable paclitaxel-eluting stent on bile duct healing after trauma in a porcine model
10.3760/cma.j.issn.1007-631X.2013.11.009
- VernacularTitle:紫杉醇生物可降解支架对猪胆管损伤愈合的影响
- Author:
Jin YANG
;
Xiujun CAI
- Publication Type:Journal Article
- Keywords:
Wounds and injuries;
Bile ducts;
Paclitaxel
- From:
Chinese Journal of General Surgery
2013;28(11):842-845
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of a biodegradable paclitaxel-eluting biliary stent on bile duct scar formation and biliary stricture by observing the healing process after stent placement in a porcine billiary model.Methods A novel biodegradable paclitaxel-eluting biliary polylactide stent was manufactured by immersion method.The efficacy of drug release for paclitaxel-eluting biliary stent was investigated by HPLC.Paclitaxel-eluting stent were surgically inserted in the bile duct of fifteen swines in experimental group while stent without paclitaxel were placed in other fifteen swines in control group.Animals were sacrificed after 1,3,6 months.The anastomic healing of the common bile duct was observed.The size of anastomosis was measured and compared between the two groups.Result A novel biodegradable paclitaxel-eluting biliary stent was manufactured.The total amount of paclitaxel released was about 281 pg (30.4％) over a month as determined with HPLC methods.There was no death,no leakage.The diameter of anastomosis in the experimental group was significantly larger than that in control group.Cholangiography did not show obvious bile duct dilatation in experimental group.Histologic examination showed less hyperplasia of the bile duct wall in the experimental group than that in control group.Conclusion Release of paclitaxel via a biodegradable stent relieves billiary stricture in porcine model and have no obvious negative influence on wound healing of the common bile duct.
