The study of association between genetic variants in sortilin-related receptor 1 and Alzheimer's disease

VernacularTitle:分拣蛋白相关受体1基因多态性与阿尔茨海默病的相关性研究
Author: Huiyan YU ; Xin GAO ; Xiangyu CENG ; Ning CHAO ; Bin QIN
Publication Type:Journal Article
Keywords: Alzheimer's disease; Polymorphism,genetic; Amyloid
From: Chinese Journal of Geriatrics 2013;32(12):1277-1280
CountryChina
Language:Chinese
Abstract: Objective To investigate the association between gene polymorphism of sortilinrelated receptor 1 (SORL1) and Alzheimer' s disease by detecting a series of single nucleotide polymorphisms (SNPs).Methods The Snapshot method was used to genotypc 6 SNPs (SNP10,19,23,24,25,27) in SORL1 and the distributions of allele and genotype of the 6 SNPs were compared between AD patients and healthy control individuals.Results There were significant differences in the genotype distributions of SNP19,23,24 and 25 between AD patients and control group (all P＜0.01).Subjects with TT genotype in SNP19 had significantly lower risk for AD and was protective for AD (OR=0.089,95％CI:0.011-0.718,P＜0.01).The AT genotype in SNP23 (OR＝3.826,95％CI:1.388～10.544,P＜0.01),CT genotype in SNP24(OR=5.935,95％CI:1.774-19.853,P＜0.01)and CT genotype in SNP25(OR=5.754,95％CI:2.007-16.496,P＜0.01)had higher risks for AD.Conclusions SORL1 gene variants of SNP19,23,24 and 25 might be the important risk factors for late-onset AD.